2025 Annual Report
Annual Report
January 2026 news from the Sec Gen
News

January 2026 news from the Sec Gen

Dear colleagues and friends,As we begin a new year, I would like to thank you for your continued engagement and trust in ECETOC. 2026 promises to be an exciting and dynamic year, and I am pleased...
ECETOC launches Secondee Programme
News

ECETOC launches Secondee Programme

Looking for an extra challenge? A next step to help develop your career? Consider applying for our Secondee Programme!ECETOC is looking for early-career scientists currently working at a member co...
HSSD Tool

HSSD Tool

This software was developed by a consortium of partners to facilitate the uptake of novel approaches to estimate aquatic threshold concentrations (e.g. the concentration at which 5% of the species are exposed above their EC50, HC5).
The Human Exposure Assessment Tools Database (heatDB)

The Human Exposure Assessment Tools Database (heatDB)

heatdb is a public directory of exposure data sources as well as available tools for exposure
NanoApp

NanoApp

ECETOC’s NanoApp is a tool designed to define the boundaries of sets of similar nanoforms and to generate a justification for the REACH registration.
Targeted Risk Assessment (TRA)

Targeted Risk Assessment (TRA)

The Targeted Risk Assessment (TRA) estimates exposures to workers, consumers and the environment that arise during a series of events.
Chronic fish case studies towards an IATA

Chronic fish case studies towards an IATA

Why?Hazard and safety assessments for the pelagic compartment often rely on in vivo studies using a single fish species, raising ethical concerns and uncertainty in terms of extrapolation....
Estimating the environmental release of Synthetic Polymeric Microparticles from Products

Estimating the environmental release of Synthetic Polymeric Microparticles from Products

Why?REACH restriction: SPM use restricted; emissions reporting required by May 2027. Gap: No analytical methods available to measure SPM emissions. Solution: Draft SPERC-based approac...
Case Studies on Reliability and Relevance Considerations during Validation of NAMs

Case Studies on Reliability and Relevance Considerations during Validation of NAMs

Why?Validation of NAMs is often overlooked despite its importance for regulatory use. Traditional validation methods are less suitable for NAMs, which focus on key events rather than apical...

Immunotoxicity-NeurotoxicityDevelopmental neurotoxicity (DNT)

Publications

Thresholds in chemical respiratory sensitisation
Article

Thresholds in chemical respiratory sensitisation

Brussels, May 2015 A variety of chemicals are known to cause allergic sensitisation of the respiratory tract associated with allergic rhinitis and asthma. It is generally accepted that the development...
Technical Report

TR 095 Vol II – The Toxicology of Glycol Ethers and its Relevance to Man (Fourth Edition) Volume II – Substance Profiles

TR 095 Vol II : The Toxicology of Glycol Ethers and its Relevance to Man (Fourth Edition) Volume II - Substance Profiles | March 2005 This report provides an update of an earlier ECETOC reviewa<...
Technical Report

TR 095 Vol I – The Toxicology of Glycol Ethers and its Relevance to Man (Fourth Edition) Volume I

TR 095 Vol I : The Toxicology of Glycol Ethers and its Relevance to Man (Fourth Edition) Volume I | March 2005 This report provides an update of an earlier ECETOC reviewa of a number of im...
Technical Report

TR 081 – Human Acute Intoxication from Monochloroacetic Acid: Proposals for Therapy

TR 081 : Human Acute Intoxication from Monochloroacetic Acid: Proposals for Therapy | November 2001 The industrial chemical monochloroacetic acid (MCAA) is used mainly in carboxylation reactions. It...
Technical Report

TR 077 – Skin and Respiratory Sensitisers: Reference Chemical Data Bank

TR 077 : Skin and Respiratory Sensitisers: Reference Chemical Data Bank | August 1999 Certain chemicals can cause occupational and consumer health problems, such as allergic contact dermatitis and al...
Technical Report

TR 075 – Organophosphorus Pesticides and Long-term Effects on the Nervous System

TR 075 : Organophosphorus Pesticides and Long-term Effects on the Nervous System | December 1998 Organophosphorus pesticides (OPps) have been used for decades. In view of their potent biological effe...
Technical Report

TR 070 – Chronic Neurotoxicity of Solvents

TR 070 : Chronic Neurotoxicity of Solvents | February 1996 This review addresses the question whether a discrete specific neurological syndrome that is casually related to chronic low-level exposure...
Monograph

Monograph 021 – Immunotoxicity: Hazard Identification and Risk Characterisation

Mono 021 : Immunotoxicity: Hazard Identification and Risk Characterisation | September 1994...
Special Report

Special Report 06 – Interpretation – Evaluation of the Neurotoxic Potential of Chemicals in Animals

SR 06 : Interpretation - Evaluation of the Neurotoxic Potential of Chemicals in Animals | December 1993...

Task Forces

Case Studies on Reliability and Relevance Considerations during Validation of NAMs

Case Studies on Reliability and Relevance Considerations during Validation of NAMs

Why?Validation of NAMs is often overlooked despite its importance for regulatory use. Traditional validation methods are less suitable for NAMs, which focus on key events rather than apical...